A man and wife are terrorized by Mad Scientist Dr. Callistratus who was executed but has returned to life with a heart transplant. Along with his crippled assistant Carl, the 'anemic' Mad Scientist, believed to be a vampire, conducts blood deficiency research on the inmates of a prison hospital for the criminally insane to sustain his return to life.

In a small Southern American town, Paul, who is known for having sexual relations with every girl in town, falls in love with his best friend's younger sister who is a virgin. Paul must try to prove to everyone that this time he is in love rather than in lust.

Kirk Bennett is falsely sentenced to death for killing blackmailer Mavis Marlowe, ex-wife of nice-guy drunk Martin Blair. Bennett's stand-up wife Catherine tries to prove him innocent, enlisting the aid of Blair, who falls in love with her. Bennett's execution draws near as the two pose as piano player and singer, trying to get the goods on sleazy nightclub owner Marko, a prime suspect. Failing to nail Marko, Catherine goes off to meet with her husband, scheduled to die the next morning, and Blair slips into an alcoholic stupor before the real killer is revealed.

Posing as a hangman, Mace Bishop arrives in town with the intention of freeing a gang of outlaws, including his brother, from the gallows. Mace urges his younger brother to give up crime. The sheriff chases the brothers to Mexico. They join forces, however, against a group of Mexican bandits.

An American travels to East Africa, where he tries to find out how his brother died.

This remake of West of Zanzibar (1928) made four years later tries to outdo the Lon Chaney original in morbidity. From a wheelchair a handicapped white man rules an area of Africa as a living god. He rules the local natives through superstition and stage magic and he rules the few white people through sadism, keeping them virtual prisoners. He lives for the day he can avenge himself horribly on the man who stole his wife and crushed his spine. Strong and macabre stuff in a nearly forgotten horror film.