Protein Tyrosine Phosphatases: Structure, Signaling and Drug Discovery
Lalima G. Ahuja, "Protein Tyrosine Phosphatases: Structure, Signaling and Drug Discovery"
English | ISBN: 3110426439 | 2018 | 296 pages | EPUB | 21 MB
English | ISBN: 3110426439 | 2018 | 296 pages | EPUB | 21 MB
Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of signaling networks that underlie the cellular workings of human physiology. Initially passed-off as housekeeping genes; these proteins were only acknowledged to maintain a steady background of phosphotyrosine levels in the cell. However, recent progress in studying their role in embryonic development and human disease has established their importance as regulators of signal regulation. Convincing evidence shows the role of mutations in these proteins to cause and/or intensify the severity of various diseases including metabolic and neurological disorders and also cancer. Protein tyrosine phosphatases have slowly, yet convincingly become crucial targets for therapeutic intervention of various human pathophysiologies.
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