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The sense of touch is fundamental during the interaction between humans and their environment; in virtual reality, objects are created by computer simulations and they can be experienced through haptic devices. In this context haptic textures are fundamental for a realistic haptic perception of virtual objects.

The challenge for the biosciences in the twenty-first century is to integrate genome sequencing information into a better understanding of biology, physiology, and human pathology. Such attempts at integration are moving the world toward a new generation of bioscience and bioengineering, where biological, physiological, and pathological information from humans and other living animals can be quantitatively described in silico across multiple scales of time and size and through diverse hierarchies of organization — from molecules to cells and organs, to individuals. To "harness" such complexity, international communities of integrative bioscientists and bioengineers aim to establish frameworks and information infrastructures for describing biological structures and physiological functions on multiple scales of time and space. This textbook includes a public platform to describe physiological functions using mathematical equations and guides the reader to perform mathematical modeling and computer simulations, to combine existing models as well as to create new models. Accessible to biologists, physiologists, and students of the sciences, with illustrative details provided when necessary, this book seeks to achieve a systematic way of harnessing biological complexity. Sharing the databases among communities worldwide will help to find comprehensive answers to all the important questions.

There has been a long history of interaction between mathematics and physiology. This book looks in detail at a wide selection of mathematical models in physiology, showing how physiological problems can be formulated and studied mathematically, and how such models give rise to interesting and challenging mathematical questions. With its coverage of many recent models it gives an overview of the field, while many older models are also discussed, to put the modern work in context.

In 1979, the Nobel Prize for Medicine and Physiology was awarded jointly to Allan McLeod Cormack and Godfrey Newbold Houns eld, the two pioneering scienti- engineers primarily responsible for the development, in the 1960s and early 1970s, of computerized axial tomography, popularly known as the CAT or CT scan. In his papers [13], Cormack, then a Professor at Tufts University, in Massachusetts, dev- oped certain mathematical algorithms that, he envisioned, could be used to create an image from X-ray data. Working completely independently of Cormack and at about the same time, Houns eld, a research scientist at EMI Central Research Laboratories in the United Kingdom, designed the rst operational CT scanner as well as the rst commercially available model. (See [22] and [23]. ) Since 1980, the number of CT scans performed each year in the United States has risen from about 3 million to over 67 million. What few people who have had CT scans probably realize is that the fundamental problem behind this procedure is essentially mathematical: If we know the values of the integral of a two- or three-dimensional fu- tion along all possible cross-sections, then how can we reconstruct the function itself? This particular example of what is known as an inverse problem was studied by Johann Radon, an Austrian mathematician, in the early part of the twentieth century.

As the current millennium steams towards a close, one cannot help but look with amazement at the incredible amount of progress that has been achieved in medicine in just the last few decades. A key contributing factor to this success has been the importation and blending of ideas and techniques from disciplines outside the traditional borders of medical science. In recent years, the most well-known example is the cross-pollination between molecular biology and medicine. Advances driven by this potent combination have spawned the vision of a future where cures based on gene therapy become commonplace. Yet, as we continue our search for "magic bullets" in the quest to eradicate disease, it important to recognize the value of other less-heralded interdisciplinary efforts that have laid a large part of the foundation of present-day medicine. In pulmonary medicine, the contribution from the bioengineers (a diverse collection of individuals cross-bred to various degrees in mathematical modeling and experimental physiology) has been larger and more sustained than in many other medical specialties.

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In the first part, we start from Blender's default cube and turn it into a detailed coffee bar, using only one reference

We could start writing this book by saying, with several other authors, that the brain is the most powerful and complex information processing device known, whether naturally developed or created artificially. Although we fully agree with this statement, in doing so we would be misleading the reader, in the sense that the present book basically aims to formalize the knowledge concerning brain physiology accumulated over the past few decades. Instead of merely describing the complexity of the cerebral str- ture or presenting a collection of commentaries and reviews of interesting experimental results, we take into account novel achievements in quantum information and quantum computation, and avail ourselves of recently - veloped mathematical tools. Neuroscience was bom in the 19'~ century with the works of Paul Brocca. However, this fledgling field experienced a boom only in recent times, following the development of powerful non-invasive techniques for probing the neural circuitry supporting the complex cognitive functions of the human brain. Although sophisticated mathematical models and phy- cal theories are the basic tools behind the conceptual foundations and a- lytical implementation of these modem techniques, to the best of our knowledge no effort was made to formalize the actual knowledge about brain function into a coherent theoretical framework incorporating the - cent developments in mathematical and physical science. Addressing this lack was our first motivation in writing this book.