Cancer Field Surgery in Gynecologic Oncology
Cancer Field Surgery in Gynecologic Oncology: Principles and Practice
English | 2025 | ISBN: 3031830296 | 276 Pages | PDF (True) | 79 MB
English | 2025 | ISBN: 3031830296 | 276 Pages | PDF (True) | 79 MB
This book encompasses the results of two decades of research on locoregional spread of gynecologic cancer, which put forth the ontogenetic cancer field model and its clinical translation in terms of ontogenetic tumor staging and cancer field surgery, particularly for carcinomas of the lower female genital tract. The ontogenetic cancer field model describes the propagation of malignant tumors within distinct permissive tissue regions determined by the development of the tissue from which the neoplasm originated. As the morphogenesis of multicellular animals proceeds stepwise through bifurcational cell fate specification within tissue regions dictated by the positional identity and plasticity of the precursor cell populations, tumor formation during malignant progression occurs as a stepwise process in the reverse direction with regard to positional identity and plasticity.