This book analyzes how sound choices can be made in Dutch health care policies, and shows why they are necessary, urgent, and even inevitable. Analyzing the current functioning and funding of the Dutch health care system, this book shows how three dimensions of sustainability – financial, staffing and societal – are under increasing pressure. This study explores priority setting in health care and calls for well-informed, clear and sometimes uncompromising choices in the allocation of means and personnel. This is necessary in order to maintain accessible and high-quality care for all, and to improve public health. Making balanced choices in health care is of particular importance to vulnerable groups whose voices may not be heard as readily or effectively in the public debate, and whose interests are more easily crowded out. Prioritizing in the domain of public health care is first and foremost a political responsibility, but also one for health care providers across the system and ultimately also for citizens. While this work focuses on the Netherlands, similar processes are at play across the developed economies, making it broadly relevant to policy makers, health care professionals and health care (policy) researchers grappling with the questions surrounding the sustainability of public health care.

Set in Springfield, the average American town, the show focuses on the antics and everyday adventures of the Simpson family; Homer, Marge, Bart, Lisa and Maggie, as well as a virtual cast of thousands. Since the beginning, the series has been a pop culture icon, attracting hundreds of celebrities to guest star. The show has also made name for itself in its fearless satirical take on politics, media and American life in general.

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Felix Mendelssohn Bartholdy was born in Hamburg in 1809 and died in Leipzig at the age of 38. He was very early musically gifted. Mendelssohn performed in public at the age of 9 and composed already from the age of 11. As a pupil of Friedrich Zelter, who was a friend of Goethe, Mendelssohn composed at the age of 17 his first masterpiece: the Overture to the Midsummer Night's Dream. This is included in the extensive CD box as well as a large number of other known or less known pieces by him. The String Quartet in F Minor Op. 80 - written in memory of his beloved sister Fanny - which was recorded in this collection by the Aurora String Quartet is undoubtedly one of his most beautiful works. The Gächinger Kantorei with Helmuth Rilling, the Bach Collegium Stuttgart, the Bartholdy Piano Quartet, the Heidelberger Sinfoniker with Thomas Fey, Ana-Marija Markovina and other renowned interpreters and orchestras can also be heard.

Every cell, tissue, organ and organism is competent to use signs to exchange information reaching common coordinations and organisations of both single cell and group behavior. These sign-mediated interactions we term biological communication. The regulatory system that works in development, morphology, cell fate and identity, physiology, genetic instructions, immunity, memory/learning, physical and mental disease depends on epigenetic marks. The communication of cells, persistent viruses and their defectives such as mobile genetic elements and RNA networks ensures both the transport of regulatory instructions and the reprogramming of these instructions. But how are the different states of the epigenome orchestrated? The epigenetic pathways respond to various signaling cues such as DNA methylation, histone variants, histone modifications, chromatin structure, nucleosome remodeling, and epigenetic interactions. Epigenetic signals are responsible for the establishment, maintenance and reversal of transcriptional states that are fundamental for the cell's ability to memorize past events, such as changes in the external environment, socio-sphere or developmental cues.

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