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This book is a comprehensive review of the recent research on the lipotoxicity-related mechanisms in obesity and the development of new treatment strategies. In this second edition, the possible molecular treatment methods and their recent clinical approaches are discussed in addition to the basic mechanisms that are available and thoroughly reviewed previously. Moreover, all chapters have been reviewed, according to the current concepts and seven new chapters are added, covering obesity-related epigenetic modifications, senescence, obesity-related cancer development, endocrine disruptors, as well as nanotechnology-based clinical approaches.

This new edition presents an up-to-date, comprehensive overview of the GABAB receptor system, including a particular focus on the most recent therapeutic applications and potential. This receptor system has been implicated in several diseases and disorders, including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. The new edition is completely reworked and updated, featuring the latest pharmacological advances on baclofen and positive allosteric modulators.

Computational methods have become important techniques for drying in food processing. There are two principle computational approaches for system analysis: continuous and discrete. In the continuous approach, the governing equations can be obtained by applying the fundamental laws such as conservation of mass, momentum and energy over an infinitesimal control volume. These equations are further discretized by using a suitable discretization technique. The recovered set of algebraic equations are then solved by an applied numerical method. The discrete approach concentrates on mimicking the molecular movement within system. Recent years have witnessed a rapid development in the field of computational techniques owing to its abundant benefit to the food processing industry. The relevance of advanced computational methods has helped in understanding the fundamental physics of thermal and hydrodynamics behavior that can provide benefits to the food processing industry in numerous applications such as drying, evaporation, sterilization, mixing and refrigeration.

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This book delves into the burgeoning field of nano-biomaterials and their application in targeted drug delivery across various therapeutic domains. Through its comprehensive exploration, it offers insights into the innovative approaches and potential of biomaterial-inspired nanomedicines in revolutionizing healthcare.

This book focuses on laser-triggered nanobiomaterials for tumor inhibition. In this book, magnetic iron oxide nanoparticle-mediated cancer PTT through intratumoral or/and intravenous injection is introduced first. The benefits of intratumoral injection and the main factors affecting the retention of materials and permeability in solid tumors have been discussed. Furthermore, an attempt has been made to explore the performance of magnetic iron oxide nanoparticles after intravenous injection for tumor-targeted PTT based on several strategies. The latter part probes the gaps to improve magnetic iron oxide nanoparticle-mediated PTT through intratumoral and intravenous injection modes. This book also includes discussion on drug-loaded magnetic nanocomposites, magnetic iron oxide/Au nanocomposites, and magnetic iron oxide/semiconductor nanocrystal nanocomposites for combination cancer therapy, and enhanced cancer PTT has also been included as an integral part. This book also summarizes the most investigated photothermal agents, including noble metal nanoparticles, especially gold nanostars, hollow mesoporous copper sulfide nanoparticles, carbon-based nanoparticles, especially carbon nanotubes and graphic carbon nanocages, black phosphorous nanosheets, conjugated polymer nanoparticles, and organic dye nanoparticles.

This book, drawing from internationally renowned scales like Bayley and Gesell, develops a child developmental assessment scale based on research data from Chinese children. It stands as a meticulous creation of the Capital Institute of Pediatrics, a national-level institution for children’s development research in China. The scale demonstrates good reliability and validity, meeting psychometric standards in various statistical aspects. In the revised scale, developmental quotients are classified into six levels, distributions of percentiles for developmental quotients are provided, and screening indices for autism spectrum disorders are added. In doing so, the revised scale can not only identify developmental delays but also concurrently screen for autism spectrum disorder risks, providing a foundational reference for tracking children’s developmental status in follow-up studies. The book holds vital value and significance in fostering communication among scholars from universities and research institutions, as well as pediatricians, neurologists, and rehabilitation specialists in hospitals.

This book examines state-of-the-science telemental health interventions for children and families. It explores the adaptations necessary to provide remote formats of evidence-based models, such as parent-child interaction therapy and trauma-focused cognitive behavior therapy. Chapters provide clear descriptions of how to implement interventions in a telemental health format, a review and critique of the empirical evidence supporting them, and useful case studies. The volume addresses the use of telemental health care within parenting interventions, individual child interventions, and family interventions, with particular attention paid to the evidence base of efficacy for families from marginalized and underserved communities.

The book examines the preparation and presentation of psychological data reports for various stakeholders (e.g., teachers, parents, caregivers). It details strategies for clear and effective prose and visuals that reach beyond the narrative and emphasize data integration. Chapters are organized around specific themes contained in the overall report and its sections (e.g., cognitive, achievement, social/emotional/personality) as well as the process of data reporting, its description, and eventual communication to consumers.