"New Research Directions in DNA Repair" ed. by Clark Chen

This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.

The first section of the book aims to illustrate novel mechanistic insights into the various forms of DNA repair.
The second section of the book describes works that elucidate the interfaces between DNA repair and the various essential processes.
The final section of the book outlines strategies for clinical translation of the vast reservoir of knowledge on this topic into therapeutic, prognostic, and predictive platforms.

Contents
Preface
Section 1 Novel Insights into DNA Repair
1 Recombination Hot-Spots and Defense Players - Maintenance of Genomic Integrity
2 The Role of Multimerization During Non-Homologous End Joining
3 Epimutation in DNA Mismatch Repair (MMR) Genes
4 Evolving DNA Repair Polymerases: From Double—Strand Break Repair to Base Excision Repair and VDJ Recombination
5 Direct Repair in Mammalian Cells
6 Chromatin Remodeling in Nucleotide Excision Repair in Mammalian Cells
7 Emerging Features of DNA Double-Strand Break Repair in Humans
8 Regulation of DNA Repair Process by the Pro-Inflammatory NF-kB Pathway
Section 2 Interface with Replication, Transcription, Telomeres, and Cell Cycle Regulation
9 Relation of the Types of DNA Damage to Replication Stress and the Induction of Premature Chromosome Condensation
10 p21CDKN1Aand DNA Repair Systems: Recent Findings and Future Perspectives
11 The Role of P53 Exonuclease in Accuracy of DNA Synthesis and Sensitivity to Nucleoside Analogs in Various Compartments of Cells
12 Biological Systems that Control Transcription of DNA Repair and Telomere Maintenance-Associated Genes
13 The Endothelin Axis in DNA Damage and Repair: The Cancer Paradigm
14 DNA Repair and Telomeres —An Intriguing Relationship
Section 3 Interface with Clinical Medicine
15 Genetic Polymorphisms of DNA Repair Genes and DNA Repair Capacity Related to Aflatoxin B1 (AFBI)-lnduced DNA Damages
16 DNA Damage, DNA Repair and Cancer
17 New Potential Therapeutic Approaches by Targeting Rad51-Dependent Homologous Recombination
18 DNA Repair and Resistance to Cancer Therapy
19 DNA Base Excision Repair: Evolving Biomarkers for Personalized Therapies in Cancer
20 Nucleotide Excision Repair Inhibitors: Still a Long Way to Go
21 The Molecular Epidemiology of DNA Repair Polymorphisms in Carcinogenesis
22 Aspects of DNA Damage from Internal Radionuclides
23 Radiosensitization Strategies Through Modification of DNA Double-Strand Break Repair

DepositF