"Muscular Dystrophy" ed. by Madhuri Hegde and Arunkanth Ankala

This book provides a comprehensive overview of the various types of muscular dystrophies, genes associated with each subtype, disease diagnosis, management as well as available treatment options. This book discusses the currently available diagnostic approaches that have revolutionized clinical research.

With more than 30 different types and subtypes known and many more yet to be classified and characterized, muscular dystrophy is a highly heterogeneous group of inherited neuromuscular disorders.
Though each different type and subtype of muscular dystrophy is associated with a different causative gene, the majority of them have overlapping clinical presentations, making molecular diagnosis inevitable for both disease diagnosis as well as patient management. Pathophysiology of the different muscular dystrophies, multifaceted functions of the involved genes as well as efforts towards diagnosis and effective patient management, are also discussed.
Adding value to the book are the included reports on ongoing studies that show a promise for future therapeutic strategies.

Contents
Preface
Section 1 Introduction to Muscular Dystrophies
1 Alpha-Dystroglycanopathy
2 Nuclear Poly (A)-Binding Protein and Oculopharyngeal Muscular Dystrophy
3 Myotonic Dystrophy Type 1 (DM1): From the Genetics to Molecular Mechanisms
4 Possible Diverse Roles of Fukutin: More Than Basement Membrane Formation?
Section 2 Pathophysiology and Disease State
5 Duchenne Muscular Dystrophy and Brain Function
6 Proteomic Analysis of Signalling Pathway Deregulation in Dystrophic Dog Muscle
7 Abnormal Ion Homeostasis and Cell Damage in Muscular Dystrophy
8 Mitogen-Activated Protein Kinases and Mitogen-Activated Protein Kinase Phosphatases in Regenerative Myogenesis and Muscular Dystrophy
9 Synaptic Changes at the Spinal Cord Level and Peripheral Nerve Regeneration During the Course of Muscular Dystrophy in MDX Mice
10 Altered Gene Expression Pathways in Duchenne Muscular Dystrophy
Section 3 Disease Diagnosis and Management
11 Effects of Dietary Phosphate on Ectopic Calcification and Muscle Function in mdx Mice
12 Rehabilitation in Muscular Dystrophies: Changing Approach
13 Database of Wards for Patients with Muscular Dystrophy in Japan
14 Diagnosis of the Muscular Dystrophies
15 Advances in Molecular Analysis of Muscular Dystrophies
16 Motor Function Measure Scale (MFM): New Instrument for Follow-Up Brazilian Patients with Neuromuscular Disease
17 Strength and Functional Measurement for Patients with Muscular Dystrophy
Section 4 Therapy
18 Muscle Satellite Cells and Duchenne Muscular Dystrophy
19 Exon Skipping and Myoblast Transplantation: Single or Combined Potential Options for Treatment of Duchenne Muscular Dystrophy
20 Duchenne Muscular Dystrophy: Therapeutic Approaches to Restore Dystrophin
21 Stem Cell Based Therapy for Muscular Dystrophies: Cell Types and Environmental Factors Influencing Their Efficacy
22 Genetic Therapy for Duchenne Muscular Dystrophy: Principles and Progress
Section 5 Current Advances and Future Promises
23 From Basic Research to Clinical Trials: Preclinical Trial Evaluation in Mouse Models
24 A Two Stage Model of Skeletal Muscle Necrosis in Muscular Dystrophy - The Role of Fiber Branching in the Terminal Stage
25 Myotonic Dystrophy Type 1: Focus on the RNA Pathology and Therapy
26 Duchenne Muscular Dystrophy: Experimental models on Physical Therapy


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