"Drug Metabolism and Pharmacokinetics"ed. by Mithun Rudrapal, Rosario Pignatello

This volume delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in pharmacokinetic, metabolomic, and bioanalytical studies.

The evaluation of various pharmacokinetic parameters such as aqueous solubility, lipophilicity, cell permeability, bioavailability, protein binding, and metabolism and elimination half-life, drug–drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent.
Key Features:
• Presents pharmacokinetic and biotransformation parameters used for pre-clinical safety evaluations
• Depicts experimental and biophysical techniques used in bioanalytical and metabolomic studies
• Summarizes in silico, in vitro, and in vivo methods used in drug–enzyme interactions, drug– drug interactions, and toxicokinetics
Written by a global team of experts, this book is a valuable resource for drug discovery scientists, drug developers, medicinal chemists, pharmacologists, biochemists, clinicians, biomedical scientists, healthcare professionals, researchers, teaching faculty, and students.

Contents
1. Pharmacokinetics and Drug Metabolism with Special Reference to Herbal Formulations
2. Drug Metabolism: Phase I and Phase II Metabolic Pathways
3. Drug Induced Hematological Disorders: An Undiscussed Stigma
4. Metabolomics: Special Emphasis on Basic Drug Discovery and Development
5. The Role of Bioinformatics in Drug Discovery: A Comprehensive Overview
6. The Modification Strategies for Enhancing the Metabolic Stabilities and Pharmacokinetics of Aptamer Drug Candidates
7. Bioactive Indanes: Development and Validation of a Bioanalytical Method of LC-MS/MS for the Determination of PH46A, a New Potential Anti-Inflammatory Agent, in Human Plasma, Urine and Faeces


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