"Bacterial Biofilm Studies Recent Advances: Formation, Regulation, and Eradication in Human Infections" ed. by Liang Wang

Written by an international team of basic and clinical researchers, the chapters of this book provide novel insights and advanced knowledge for life science researchers, clinical researchers, doctors, and other interested readers on some of the latest developments in biofilms.

Bacterial biofilm is a complex structure with diverse bacterial cells in a highly organized and ordered group within a matrix of extracellular polymeric substances they produce. Microbes attach to surfaces to develop biofilms, a sophisticated process regulated by factors such as nutritional status and biotic/abiotic surface features. An established biofilm structure mainly comprises bacterial cells, proteins, nucleic acid, and exo-polysaccharides that are extracellular macromolecules excreted as tightly bound layers in microbes, providing a perfect niche for bacteria to exchange genetic material between cells. In addition, bacterial cells in the matrix also communicate via quorum sensing, which greatly impacts biofilm processes. Under clinical circumstances, bacterial biofilm shows great resistance to antibiotics, disinfectants, and body defense systems, making it difficult for clinicians to eradicate and facilitate many infectious disease processes, leading to chronic infections of patients with long-term hospitalization and high mortality rates. Therefore, it is very important to understand the recent advances in forming, regulating, and eradicating biofilms in human infections to better prevent, control, and treat biofilm infections in humans.

Contents
1. Bacterial Biofilms in Human Infection – An Urgent Problem That Needs to Be Solved
2. Formation, Regulation, and Eradication of Bacterial Biofilm in Human Infection
3. Bacterial Biofilm Eradication in Human Infections
4. Campylobacter: Virulence Factors and Pathogenesis
5. Pathobiology, Public Health Significance, and Control of Campylobacter Infections
6. Quorum Sensing in Biofilm


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