"BRCA1 and BRCA2 Mutations: Diagnostic and Therapeutic Implications" ed. by Mani T. Valarmathi

This book consolidates the recent advances in BRCA-related cancer biology and therapeutics, covering a wide spectrum of interrelated topics. Chapters cover a wide range of topics, such as BRCA discovery, BRCA structure and function, BRCA-associated cancers, BRCA genetic testing and counselling, and more. This book is a valuable resource not only for medical and allied health students but also for researchers, clinical and nurse geneticists, genetic counselors, and physician assistants.

Mutations in the BRCA1/2 genes are the most common cause of hereditary breast and ovarian cancer (HBOC), and HBOC is an autosomal dominant cancer predisposition syndrome. Individuals with HBOC have a high risk for breast and ovarian cancers and a moderate risk for other cancers, such as prostate, pancreatic, melanoma, and fallopian tube cancers. The goal of screening individuals at high risk of familial cancer is either prevention (such as a change in lifestyle or diet) or early detection of cancer. The identification of BRCA mutation carriers is important, since increased surveillance, drug therapy, and prophylactic surgery can reduce cancer-related morbidity and mortality. In recent years, there has been substantial development in BRCA-associated hereditary breast and/or breast-ovarian cancer research and its clinical applications.

Contents
1. The Influence of BRCA1/2 Genes Mutations on Hereditary Breast and Ovarian Cancer Syndrome - Is it in your Genes?
2. Discovery of BRCA Mutations: Historical Perspective of Its Scientific, Clinical and Social Impact
3. BRCA Biological Functions
4. The Fundamental Role of BARD1 Mutations and Their Applications as a Prognostic Biomarker for Cancer Treatment
5. BRCA Gene Mutations and Prostate Cancer
6. Genomic Consequences of Ovarian Cancer with Respect to DNA Damage and Repair Mechanism
7. Implications of BRCA1 and BRCA2 Mutations in Mexico
8. Quality of Life is Essential: Implications for Diagnosis and Treatment for BRCA1/2 Germline Mutations


More : You find here