Fetal Alcohol Spectrum Disorders: Concepts, Mechanisms, and Cure

by Sushil Sharma (Author)

Alcoholism exerts a high genetic as well as epigenetic load and may be regarded as one of the most prevalent, identifiable, and preventable neuropsychiatric illnesses afflicting modern society today. Alcohol constituted 3.2% of all worldwide deaths in the year 2006 and is associated with >60 diseases, including fetal alcohol spectrum disorder (FASD), cancers, cardiovascular diseases, liver cirrhosis, neuropsychiatric disorders and life-threatening injuries. Fetal alcohol spectrum disorder (FASD) is a collective term representing fetal abnormalities associated with maternal alcohol abuse. The most unique feature of this book is that it introduces original concepts of mitochondrial bioenergetics, genomics, and epigenomics to successfully manage FASD. Particularly, mitochondrial bioenergetics-based CB prevention/inhibition, charnolophagy induction, and charnolophagosome and charnolosome stabilization are novel therapeutic targets for safe and effective clinical management of FASD. These concepts and mechanisms are based on several years of basic research and original discoveries by the author

Dr Sushil Sharma is Academic Dean at the American International School of Medicine, Georgetown, Guyana, South America, Corporate HQs. 1755 Stony Mountain Bulevard, Atlanta, Georgia, U.S.A. He was Professor and Course Director of Pharmacology at the Saint James School of Medicine, St Vincent. He received Ph.D. in Neuropharmacology from A.I.IM.S, New Delhi; Radiopharmaceutical Training from BARC, Bombay, GE, Siemens, Agilent Technologies, & Cardinal Health in USA; Served as Research Officer in AIIMS:1979-88); awarded Royal Society Fellowship (UK:1988-89); MHRC Post-doctoral Fellowship (Canada: 1989-91); Research Officer (University of Montreal:1993-94); Research Associate (McGill University:1994-95); Offered Deputy Director (Scientist-E) Position in Defense Research Institute (New Delhi -93-97); Senior Scientific Officer (Clinical Research Institute of Montreal:1995-97); Research Scientist (University of Manitoba:1997-99); Assistant Professor 2000-04; Associate Professor & Director (Research) UND School of Medicine, Grand Forks:2004-08); Associate Professor & Director (Methodist Hospital) & Research Scientist (University Texas Medical Center:2008-11). Organized and Chaired several World Conferences; was awarded 5 Gold Medals; Certificate of Honor IT Nano-2014 Conference, Boston. (Original Discoveries: Electromicroinjector; Charnoly Body in Purkinje Neurons, IL-10 Receptors on Cortical Neurons, & MTs-Gene-Manipulated Mice)

Research Interests: Neuropharmacology; Disease-Specific Biomarkers, Nanomedicine, Stem Cells, Regenerative Medicine, Neurodegenerative diseases, Multimodality Molecular Imaging, Personalized Theranostics, Nutrition