This proceedings volume highlights the state-of-the-art knowledge related to optimization, decisions science and problem solving methods, as well as their application in industrial and territorial systems. It includes contributions tackling these themes using models and methods based on continuous and discrete optimization, network optimization, simulation and system dynamics, heuristics, metaheuristics, artificial intelligence, analytics, and also multiple-criteria decision making. The number and the increasing size of the problems arising in real life require mathematical models and solution methods adequate to their complexity.