The Amazing Spider-Man Vol. 04 - The Life & Death of Spiders (2006)

Collects Amazing Spider-Man (1999) #46-50.
Was the radioactive spider bite that granted Peter Parker his amazing abilities an accident…or something more? Now the mysterious Ezekiel offers him a shocking explanation: Peter may be the latest in an ancient line of humans gifted with supernatural spider powers. But Peter won't have much time to ponder his origins, as his existence has drawn the attention of Shathra, an otherworldly being who sees Spider-Man as her prey. Overpowered and on the run, the web-slinger has only his wits and his courage to keep him from becoming Shathra's next meal. The Life and Death of Spiders also features the long-awaited reunion of Mary Jane and Peter. With one last chance to be together, will this couple finally reconcile?